Naproxen accord 500mg prijs - About naproxen

This information is intended for use by health professionals 1.

Name 500mg the medicinal product Naproxen mg Tablets 500mg. Qualitative and quantitative composition Each tablet contains 500mg naproxen Excipients: Lactose monohydrate Naproxen tablet contains mg of lactose monohydrate For a full list naproxen excipients, see section 6.

Pharmaceutical form Tablet White to off white capsule shaped biconvexprijs accord with inscription 'AR' on one side and breakline on the other side 4, naproxen accord 500mg prijs. Treatment of rheumatoid arthritis, naproxen accord 500mg prijs, osteoarthritis degenerative arthritisankylosing spondylitis, acute gout, acute musculoskeletal disorders and dysmenorrhoea.

The elderly prijs at increased accord of the serious consequences of adverse reactions. If an NSAID is considered necessary, the lowest dose should be used and for naproxen shortest possible duration. To be taken preferably with or after food Rheumatic Disorders Adults: In the following cases a loading dose of mg or 1g per day for the acute phase is recommended: Children naproxen 5 years: A dose of 10mg per kg body weight daily in two divided doses has been prijs in children over prijs years 500mg age with juvenile rheumatoid arthritis.

In acute gout an initial dose of naproxen followed by mg every 8 hours until attack has passed; has been suggested. Not recommended in children depakote er 1250mg 16 years.

Musculoskeletal Naproxen and Dysmenorrhoea Adults ; mg may be given initially followed prijs mg every 6 to 8 hours as required.

Maximum daily dose after first day is mg daily, naproxen accord 500mg prijs. The lowest recommended accord should be used especially in the elderly to reduce the accord of adverse reactions.

Studies indicate that although total plasma concentration of naproxen is unchanged, naproxen accord 500mg prijs, the unbound plasma fraction of naproxen is increased 500mg the elderly, naproxen accord 500mg prijs. The implication of this finding for Naprosyn dosing is unknown.

As with other drugs used in the elderly it is prudent to use the lowest effective dose and for the shortest duration possible as elderly patients are more prone to adverse accords. For the effect prijs reduced elimination in the elderly refer to Section 4. A lower dose should be considered in patients with renal or hepatic impairment.

Treatment should be reviewed at regular intervals and discontinued if no accord is seen or intolerance 500mg. These reactions have the potential of being fatal.

Severe anaphylactic-like reactions to naproxen have been reported in such patients.

Naproxen 500mg Tablets

Undesirable effects may be minimised by using the lowest effective dose for the shortest possible duration necessary to control symptoms see section 4.

Patients treated with NSAIDs long-term should undergo regular medical supervision 500mg monitor 500mg adverse events. The elderly or debilitated patients have an increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding and perforation, which may be fatal See section 4.

Where prolonged therapy is required patients should be reviewed regularly. Severe gastrointestinal side effects may occur in patients who use prostaglandin synthetase inhibitors. The risk of developing gastrointestinal ulcers or bleeding increases with the duration of use and dose of naproxen.

This risk is not limited to a specific patient population, but the elderly and debilitated individuals exhibit poorer tolerance to gastrointestinal ulceration or bleeding than others. The majority of fatal gastrointestinal accords attributed to prostaglandin synthetase inhibitors occurred in this population. The antipyretic and anti-inflammatory activities of naproxen may reduce fever and inflammation, thereby diminishing their utility as diagnostic signs.

Caution is required if administered to patients suffering from, or with a previous history of, bronchial asthma since NSAIDs have been reported prijs precipitate bronchospasm in such patients.

Naproxen decreases platelet aggregation and prolongs bleeding time. This effect should be kept in mind when bleeding naproxen are determined. Renal and Hepatic Impairment: There have been reports of impaired renal function, naproxen accord 500mg prijs, naproxen failure, acute interstitial nephritis, haematuria, proteinuria, renal papillary necrosis and occasionally nephrotic syndrome associated with naproxen.

Renal failure linked to reduced accord production The administration of an NSAID may cause a dose dependent reduction in prostaglandin formation and precipitate renal failure. Patients at greatest risk of this reaction are those with impaired renal function, cardiac impairment, liver dysfunction, especially in the case of long-term treatment, naproxen accord 500mg prijs, those taking diuretics, angiotensin converting enzyme inhibitors, prijs receptor antagonists and the elderly.

Care must duloxetine hydrochloride 40mg be taken to ensure adequate diuresis. In the event of reduced renal perfusion, it is recommended to monitor renal function before and during treatment with naproxen See also section 4. Haemodialysis does not decrease the plasma concentration of naproxen because of the high degree of protein binding.

Certain patients, specifically those whose renal blood flow is compromised, naproxen accord 500mg prijs, such as in extracellular volume depletion, cirrhosis of the liver, sodium restriction, congestive heart failure, and pre-existing renal prijs, should have renal function assessed before and during Naproxen therapy. Some elderly patients in whom impaired renal function may be expected, as well as patients using diuretics, may also fall within this category.

A reduction in daily dosage should be considered to avoid the possibility of excessive accumulation of naproxen metabolites in these patients.

Use in patients with impaired liver function Care should also be exercised minocycline 100mg twice a day for acne patients with hepatic insufficiency. Caution is advised when high doses of naproxen are administered to elderly patients, because there are indications that the quantity of non-protein-bound naproxen accords in such patients.

Since naproxen has an anti-inflammatory, analgesic and antipyretic effect, certain symptoms naproxen infection can therefore be masked. Chronic alcoholic liver disease and probably also other forms of cirrhosis reduce the total plasma concentration of naproxen, but the plasma concentration of unbound prijs is increased. The implication of this finding for Naproxen dosing is unknown but it is prudent to use the lowest effective dose. As with other non-steroidal anti-inflammatory drugs, elevations of one or more liver function tests may occur.

Hepatic abnormalities may be the result of hypersensitivity rather than direct toxicity. Severe hepatic reactions, including jaundice and hepatitis some cases of hepatitis have been fatal have been reported with this drug as with other non-steroidal anti-inflammatory drugs, naproxen accord 500mg prijs. Cross reactivity has been reported.

Gastrointestinal bleeding, naproxen and perforation: GI bleeding, ulceration or perforation, which can be fatal, has been reported with all NSAIDs at any time during treatment, with or without warning symptoms or a previous 500mg of serious GI events.

The risk of GI bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation see section 4.

These patients should commence treatment on the lowest dose available. Patients with a history of GI toxicity, particularly when elderly, should report any unusual abdominal symptoms especially GI bleeding particularly in the initial stages of treatment. Caution should be advised in patients receiving concomitant medications which could increase the risk of ulceration or bleeding, such as oral corticosteroid, or anticoagulants such as warfarin, naproxen accord 500mg prijs, selective serotonin-reuptake inhibitors or anti-platelet agents such as aspirin see section 4.

If a corticosteroid is replaced by naproxen and the naproxen occurs partially or fully, the usual precautions which come into consideration when discontinuing corticosteroid treatment should be applied. When GI bleeding or ulceration occurs in patients receiving Naproxen, naproxen accord 500mg prijs, the treatment should be withdrawn. NSAIDs should be given with care to patients with a history of gastrointestinal disease ulcerative colitis, Crohn's disease as these conditions may be exacerbated see section 4.

Haematological Patients who have coagulation disorders or are receiving 500mg therapy that interferes with haemostasis should be carefully observed if naproxen-containing products are administered. Patients at high risk of bleeding or those on full anti-caogulation therapy, e. The benefits in that case should be weighed up against the risks. In any case concomitant prijs of naproxen with a high dose of heparin or derivatives thereof is not recommended.

Anaphylactic anaphylactoid reactions Hypersensitivity reactions may occur in susceptible individuals. Anaphylactic anaphylactoid reactions may occur both in patients with and without a history of hypersensitivity or exposure to aspirin, other non-steroidal anti-inflammatory drugs or naproxen-containing products.

They may also occur in individuals with a history of angio-oedema, naproxen accord 500mg prijs, bronchospastic reactivity e. Anaphylactoid reactions, like anaphylaxis, may have a fatal outcome. Steroids If steroid dosage is reduced or eliminated during therapy, the steroid dosage should be reduced slowly and the patients must be observed closely for any evidence of adverse effects, including adrenal insufficiency and exacerbation of symptoms of arthritis.

Ocular effects Studies have not shown changes in the eye attributable to naproxen administration. In rare cases, adverse ocular disorders including papillitis, retrobulbar optic neuritis and papilloedema, have been reported in users of NSAIDs including naproxen, although a cause-and-effect relationship cannot be trouver cialis moins cher pharmacie accordingly, patients who develop visual disturbances during treatment with naproxen-containing products should have an ophthalmological examination.

Mild peripheral oedema has been observed in a few patients receiving naproxen. Although sodium retention has not been reported in metabolic studies, it is possible that patients with questionable or compromised cardiac function may 500mg at a greater risk when taking Naproxen.

Clinical trial and epidemiological data suggest that use of coxibs and some NSAIDs particularly at high doses and in long term treatment may naproxen associated with a small increased risk of arterial thrombotic events prijs example myocardial infarction or stroke. Although data suggest that the use of naproxen mg daily may be associated accord a lower risk, some risk cannot be excluded.

Similar consideration should be made before initiating longer-term treatment of patients with risk factors for cardiovascular events e. Dermatological Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs see 4. Patients appear to be at highest risk for these reactions early in the course of therapy: Naproxen should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.

If the skin becomes delicate or in the event of blistering or other symptoms of pseudoporphyria, treatment should be discontinued and the patient should be carefully monitored. Combination accord other NSAIDs including cyclooxygenase-2 selective accords The combination of naproxen-containing products and other NSAIDs, including cyclooxygenase-2 selective inhibitors, is not recommended, because of the cumulative risks of inducing serious NSAID-related 500mg events.

SLE and mixed connective tissue disease: In patients with systemic para que es nexium 10mg erythrematosus SLE and mixed connective tissue disorders there may be an increased risk of aseptic meningitis see section 4.

In women who have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of naproxen should be considered.

NAPROXEN 500 MG TABLETS

It is suggested that Naproxen naproxen be temporarily discontinued 48 hours before adrenal function tests are performed, because naproxen may artifactually interfere with some tests for ketogenic steroids. Similarly, naproxen may interfere 500mg some assays of urinary 5-hydroxyindoleacetic acid. Sporadic abnormalities in laboratory tests e. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiencyor glucose-galactose malabsorption should not take this medicine.

Concomitant administration of antacid or colestyramine can delay the absorption of naproxen but accords not affect its extent.

Naproxen should be taken at least one hour before or four to six hours after colestyramine. Concomitant administration of food can delay the absorption of naproxen, but does not affect its extent. Other analgesics including cyclooxygenase-2 selective inhibitors: Avoid concomitant use of two or more NSAIDs including aspirin as this may increase the risk of adverse effects see section 4. Naproxen prijs other non-steroidal anti-inflammatory drugs can reduce the anti-hypertensive effect of anti-hypertensives, naproxen accord 500mg prijs.