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This information is intended for use by health professionals 1. Qualitative and quantitative composition Mesalazine 5-aminosalicylic acid1g per metered dose 3.
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For disease affecting the rectosigmoid region, one metered enema 1g a day for 4 - 6 weeks; for disease involving the descending colon, two metered doses 2g once a day asacol 4 - 6 weeks.
The normal adult dosage may be used unless renal function is impaired see Section 4. There is no dosage recommendation 4. Children under 2 years of age. Mesalazine is excreted buy by the kidney, mainly as its metabolite, N-acetylaminosalicylic acid.
In rats, large doses of mesalazine injected intravenously produce tubular and glomerular toxicity. Asacol should be used isoptin 240mg extreme caution in patients with confirmed mild to moderate renal impairment see section 4.
Treatment with mesalazine asacol be discontinued if renal function deteriorates. If dehydration develops, normal electrolyte and fluid balance should be restored as soon as possible. Serious blood dyscrasias have been reported very rarely with mesalazine, buy asacol enema 4g. Haematological enemas should be performed if the patient develops unexplained bleeding, bruising, purpura, anaemia, fever buy sore throat.
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Treatment should be stopped if there is suspicion or evidence of blood dyscrasia. Use of 'Asacol' during pregnancy should be with caution, and only if the potential benefits are greater than the possible hazards. Headache has also been reported. There have been rare reports asacol leucopenia, neutropenia, agranulocytosis, aplastic anaemia and thrombocytopenia, alopecia, peripheral neuropathy, pancreatitis, abnormalities of hepatic function and hepatitis, myocarditis and pericarditis, allergic and fibrotic lung reactions, lupus erythematosus-like enemas and rash including urticariainterstitial nephritis and nephrotic buy with oral mesalazine treatment, usually reversible on withdrawal.
Renal failure has been reported. Mesalazine-induced nephrotoxicity should be suspected in patients developing renal dysfunction during treatment, buy asacol enema 4g.
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Mesalazine may very rarely be associated with an exacerbation of the symptoms of colitis, Stevens Johnson syndrome buy erythema multiforme.
Other side effects observed with sulfasalazine such as enema of sperm count and function, have not been reported with 'Asacol'. Rarely, asacol irritation may occur after administration of rectal dosage forms containing mesalazine, buy asacol enema 4g. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: It is the latter which is responsible for the majority of the side effects associated with sulfasalazine therapy whilst mesalazine is known to be the active moiety in the treatment of ulcerative colitis, buy asacol enema 4g.